New medicine of our country researches and develops advantage

New medicine of our country researches and develops advantage
On June 17, on the fifth China biological industry's conference's forums of top, Sang Guowei, vice chairman of Standing Committee of the National People's Congress and academician of Chinese Academy of Engineering made keynote speech, have explained innovative medicine development strategy and current situation of our country.
At present, the awkward situation that a lot of transnational enterprises face the input of research and development too high, the risk increase, one cannot say for sure not to lose in billions of input easily. Review China, abundant disease resource and relatively low priced experimentation cost, make numerous transnational enterprises slaver over, set up and research and develop the base in China one after another. It last these advantages for to sit to pharmacy enterprises domestic,for a long time but difficult to be get better on the generation such as powder, academician Sang Guowei feels sorry too. He thinks, Chinese enterprises and research and develop the organization and should catch " twelve five " ing Develop the opportunity, strengthen big the medical industry of our country.
It is only foreign 1/25 that new medicine researches and develops the cost
In China, industry is increasing biological medicine at the speed of 26% for every year. Sang Guowei says, accelerates the development in science and technology of biological medicine at present, accelerates fostering the biological medicine industry, have already become the global common understanding. China has already become market of the third largest medicines in the world now, is close to or exceed Japan soon, become market of the second largest medicines second only to U.S.A., and with the promotion thoroughly of the medical reform, the medical market of China will be bigger and bigger.
Sang Guowei thinks, the innovative medicine of our country is researched and developed and the medical market develops, the favorable factor includes the sustained economic development, the national income increases, aging population, urbanized process are accelerated, increased etc. to the innovative input of research and development of healthy and new medicine in the country. And the new medicine development cost of China is also relatively low, it is equivalent to about 1/25 of the western developed country. These is main because new medicine of our country is researched and developed in the course the relevant expenses are lower, especially animal's experiment. In addition, there are many kinds of Diseases in our country, there is disease of the developed country, there are the diseases of developing countries, and patient has many quantity. Generally speaking, the research and development expenses that our country needs are lower than that of foreign countries.
He propose new medicine research and develop time to be long costing large, domestic enterprise can make an issue of namely that have come due medicines in patent, there are the enterprises which research and develop the foundation, can select several almost expired medicines to carry on research, "general new medicine will have the research and development cycles of 3 years, start now, try to work out two or three serious scales and model medicines, the patent of descendant's family expire in two or three years, at this moment, so long as enterprises apply, the governments will all criticize. "
He encourages China's medical industry to stress autonomous innovation and key competitiveness, let new medicine be more, big medicine is larger, the medical platform can internationalize. He introduces, " new medicine formulates the great project " Overall goal: By 2020, build our country to develop into the scientific and technological powerful country of medicine, industry big country, comprehensive innovation ability reaches the top 5 of the world, the medical industry enters the top 3, in order to realize that it is healthy and safeguarding the security of national strategy and need of the social stability to ensure the people of our country.
Make good use of new medicine of examination and approval " Yan JinKuan appears " Characteristic
New medicine is formulated in the course, a principle to be held is appraised in early days, eliminated in early days. Sang Guowei think, want, eliminate from, eliminate from early right away, eliminate until after costing much money on later stage, so early to appraise toxicity of medicine with the operations of the cell, factor, sub passway of ionization of different levels soon, eliminate drug candidate which does not have the prospect early. Supported by various special funds, each important the intersection of research and development and platform set up screen in the center, can screen the toxicity of the medicine, safe pharmacology value and importance in the innovative medicine are higher and higher.
In the new medicine clinical trial, " 0 issues are tested " after appearing now Concept,say Sang Guowei promote this medicine as soon as possible clinical trials new of, last waste of resource. But the characteristics of 0 resources are that the quantity is limited, " very limited human body exposes, less than 1% which produce the pharmacology dosage, have not treated or diagnosed the intention " . First article that 0 issue test to issue in 2009 at present.
He reminds, new medicine is formulated and must be paid attention to into nature assessment, should see too animal's experiment can totally predict the clinical result, old medicine is new by already becoming a new trend. It is compound that fixed dosage matching appears in a very important trend in the world, if naphthalene general to born and Esso U.S.A. draws thiazole, will reduce the emergence of gastric ulcer greatly. In addition, pay attention to new medicine of model to research and develop, can accelerate the development speed of the medicine greatly, lower costs, help to calculate the dosage of the first human tail, develop the course in norm.
The main developed country is greater and greater in input to new medicine in our times, it is higher and higher to develop the difficulty, success rate is extremely low. He points out, in researching and developing the expenses, from the sixties of last century to now, the input of research and development of new medicine increased nearly 7 times, it almost costs 800 million to 1 billion dollars to make a new medicine, medicines that can really make money only account for 30%. After but it is clinical to enter, 2 issues are clinical and 3 clinical miss ratios are higher, clinical to even if enter 3 issues like antineoplastic, only 5% can enter the market, after new medicine enters the clinical trial, still there is 80% of the possibility eliminated. But Sang Guowei think China different from U.S.A., U.S.A. " wide to stock, produce severely " ,It is more convenient to enter the clinical trial, but it is very difficult to list to sanction as medicines, and China is " Yan JinKuan appears " ,Having entered the clinical trial, few medicines are supervised in the department by medicine and eliminated.
Hope to appear in five years " The heavy scale bomb "
" twelve five " During this time, on which new medicines will China have an effect? Sang Guowei reveals, 16 a kind of new medicine gets the certificate in our country now, 24 varieties are being declared, nearly 500 more hopeful new medicines are carrying on research. "25% of the new medicines are biological medicine, the antibody has accounted for 1/3. There are over 4 billion dollars of sale of 4 kinds of medicines in 26 kinds of antibody medicines that F D A sanction, this is real ' heavy scale bomb ', can make a few ' heavy scale bomb 's in China while hoping ' twelve five '. " It is reported, " twelve five " in biological medicine Plan, construct, recombinate and regard key technology of antibody as optimally the intersection of antibody and storehouse, the intersection of antibody and analysis of structure, cell, solve key technology first, just have possibility that the antibody medicine breaks through.
Sang Guowei says, researches and develops the respect in the innovative medicine, impetuses of different medicines are different, chemical the intersection of medicine and hope, make many the intersection of target and order, branched target to the medicine; Traditional Chinese medicine respect emphasizes passing on, do whole function, multicomponent and complicated function of traditional Chinese medicine on the basis of passing on, and the setting-up of many kinds of storehouses, then should there should be appraisal which accords with the clinical characteristic of traditional Chinese medicine on commenting on clinically, preferably disease post-evaluation and Western medicine comment on application; Put the focal point in treatment of the target tropism in biological medicine respect. How many
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